Grad Programs
Adeboye Adejare PhD
Adeboye Adejare PhD
Professor of Pharmaceutical Sciences
Education
BS (University of Iowa)
MS (University of Iowa)
PhD, Medicinal Chemistry (Ohio State University)
Research Interests
- Drug targeting
- Mechanisms of neurodegeneration
- Chemistry of fluoroaromatic compounds
- Pharmaceutical profiling
Synopsis
My group is interested in the areas of design and synthesis of small organic molecules to probe neurodegeneration. We are also interested in in vitro models of drug absorption and ability to cross blood brain barrier; drug targeting; pharmaceutical profiling; and chemistry of fluoroaromatic compounds. The major therapeutic areas we focus on are N-methyl-D-aspartate (NMDA) receptor antagonists and gamma-secretase inhibitors. These two mechanisms have been implicated in neurodegeneration as observed in stroke and Alzheimer’s Disease. Our research was/is funded by the National Institutes of Health, the Office of Naval Research, and several pharmaceutical companies. These efforts have resulted in over 30 publications, a patent, and over 80 presentations at meetings, including invited presentations at national and international conferences. Several students from my group have received graduate degrees (MS and Ph.D.) and are employed in academia and the pharmaceutical industry.
Selected Scholarly Activity
E. Buyukbingol, A. Sisman, F. Alparslan and A. Adejare, “Adaptive neuro-fuzzy inference system (ANFIS): A new approach to predictive modeling in QSAR applications: A study of neuro-fuzzy modeling of PCP-based NMDA receptor antagonists”, Bioorganic and Medicinal Chemistry, 15, 4265-4282 (2007).
S. Sun and A. Adejare, “Fluorinated Molecules as Drugs and Imaging Agents in the CNS”, Current Topics in Medicinal Chemistry, 6, 1457-1464 (2006).
A.S. Gurkan, A. Karabay, Z. Buyukbingol, A. Adejare, E. Buyukbingol, “Syntheses of Novel Indole Lipoic Acid Derivatives and Their Antioxidant Effects on Lipid Peroxidation”, Archiv der Pharmazie, 338, 67-73 (2005).
A. M. El-Gendy and A. Adejare, “Membrane Permeability Related and Physicochemical Properties of a Novel gamma-Secretase Inhibitor”, International Journal of Pharmaceutics, 280, 47-55 (2004).
K. Madaras-Kelly, P. Michas, M. George, M.P. May and A. Adejare, “A Randomized Crossover Study Investigating the Influence of Ranitidine or Omeprazole on the Pharmacokinetics of Cephalexin Monohydrate”, Journal of Clinical Pharmacology, 44, 1391-1397 (2004).
A. M. Ogunbadeniyi and A. Adejare, “Syntheses of Fluorinated Phencyclidine Analogs,” Journal of Fluorine Chemistry, 114, 39-42 (2002).
M. R. Caira, E. Buyukbingol, A. Adejare and W.R. Millington, “Crystal Structures of the Dipeptides Glycyl-D-Glutamine and Cyclo(Glycyl-L-Glutamine)”, Analytical Sciences, 18, 1175-1176 (2002).
A. Adejare, J. Shen and A. M. Ogunbadeniyi, “Halogens Halt Aromatic Group Migration in Baeyer-Villiger Oxidation,” Journal of Fluorine Chemistry, 105, 107-109 (2000).
‡ Undergraduate Student
* Graduate Student
Contact Information
| Office location: | PharmTox 242 |
| Mailing address: | Box 80 |
| Office Phone: | 215.596.8944 |
| Email: | a [dot] adejar [at] usciences [dot] edu |