Bin Chen PhD
Bin Chen PhD
Director, Graduate Program in Pharmacology/Toxicology
Associate Professor of Pharmaceutical Sciences
PhD (Catholic University Leuven, Belgium)
Effects and mechanisms of photo-dynamic tumor vascular targeting Synthesis and evaluation of novel optical molecular probes for tumor imaging and targeting
My research focus on targeting tumor blood vessels for cancer therapy. We are particularly interested in using photo-active drugs(photosensitizers) to modify tumor vascular function. Current research projects include characterizing blood vessel structural and functional changes induced by vascular targeting therapy, studying the interaction between vascular targeting therapy and conventional tumor cellular targeting therapy, and elucidating the molecular mechanism of vascular-targeting therapy. Fluorescence imaging is an important component of our research. We have developed an integrated fluorescence-based imaging system that allows continuous non-invasive imaging in real time at different anatomic levels from the whole body level down to the subcellular level. We are also interested in studying natural products with anti-tumor activities. An ongoing project is to determine the anti-tumor mechanisms of tanshinone.
Selected Scholarly Activity
He C, Agharkar P, Chen B. Intravital microscopic analysis of vascular perfusion and macromolecule extravasation after verteporfin-mediated photodynamic therapy. Pharm Res. 2008, 25: 1873-80.
Chen B, Crane C, He C, Gondek D, Agharkar P, Savellano M, Hoopes PJ, Pogue BW. Disparity in vascular response to verteporfin-mediated vascular-targeting therapy between prostate tumor interior versus peripheral vasculature. Int J Cancer. 2008, 123: 695-701.
Chen B, Pogue BW, Luna J, Hardman R, Hoopes PJ, Hasan T. Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism and therapeutic implications. Clin Cancer Res. 2006, 10: 917-23.
Gibbs SL, Chen B, O’Hara JA, Hoopes PJ, Hasan T, Pogue BW. Protoporphyrin IX level correlates with number of mitochondria, but increases in production correlate with tumor cell size. Photochem Photobiol. 2006, 82: 1334-41.
Chen B, Pogue BW, Hoopes PJ, Hasan T. Combining vascular and cellular targeting regimens enhances the therapeutic effect of photodynamic therapy. Int J Radiat Oncol Biol Phys. 2005, 61: 1216-26.
Chen B, Pogue BW, Zhou X, O’Hara JA, Solban N, Demidenko E, Hoopes PJ, Hasan T. Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model. Clin Cancer Res. 2005, 11: 720-7.
Chen B, Pogue BW, Goodwin IA, O’Hara JA, Wilmot CM, Hutchins JE, Hoopes PJ, Hasan T. Blood flow dynamics following photodynamic therapy with verteporfin in the RIF-1 tumor. Radiat Res. 2003, 160: 452-459.
Chen B, Busan A, Landuyt W, Ni Y, Gaspar R, Roskams T, De Witte P. Potentiation of photodynamic therapy with hypericin by mitomycin C in the RIF-1 mouse tumor model. Photochem Photobiol. 2003, 78: 278-282.
Pogue BW, O'Hara JA, Demidenko E, Wilmot CM, Goodwin IA, Chen B, Swartz HM, Hasan T. Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity. Cancer Res. 2003, 63: 1025-33.
Chen B, Roskams T, De Witte P. Antivascular tumor eradication by hypericin-mediated photodynamic therapy. Photochem Photobiol. 2002, 76: 509-13.
Chen B, Roskams T, Xu Y, Agostinis P, De Witte P. Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model. Int J Cancer. 2002, 98: 284-90.
Chen B, Xu Y, Roskams T, Delaey E, Agostinis P, Vandenheede JR, De Witte P. Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model. Int J Cancer. 2001, 93: 275-82.
Chen B, De Witte PA. Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model. Cancer Lett. 2000, 150: 111-17.
|Office location:||Pharmacology/Toxicology Center Room 244|
|Mailing address:||Box 80|
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
b [dot] chen [at] usciences [dot] edu