Grad Programs
Natalia Coleman PhD
Natalia Coleman PhD
Research Assistant Professor
Education
Ph.D. Reproductive Biology/Genetics, St. Petersburg, Russia 1996; MS Genetics, St. Petersburg, Russia, 1991; BS Biology, St. Petersburg, Russia, 1989
Research Interests
Neurofibromatosis type 1
The role of NMDA receptors in learning and memory pathology
Stem cell biology and applications in biomedical research
Synopsis
We study the role of neurofibromin (a product of tumor suppressor gene Nf1) in tumorigenesis and learning difficulties associated with Nf1, using mouse embryonic stem cell-derived neurofibromatosis disease model as a pharmacological experimental system. The functions of neurofibromin are largely unknown. Systematic study of complex molecular events in signaling pathways that occur in mouse embryonic stem cells that have one (Nf1+/-), both (Nf1+/+) or neither (Nf1-/-) functional allele during in vitro differentiation are critical for better understanding of the biology of this disease and identification of potential targets.
Selected Scholarly Activity
“The role of NMDA receptors in embryonic stem cells with different levels of neurofibromin differentiation into neural cells”,Carres Martinez, Dmitri Gourevitch, Kate F. Barald, Minh Bui and Natalia Coleman*, Mid-Atlantic Pharmacology Society Annual meeting, Philadelphia, December 10, 2010.
“Comparison of MTT and BrdU assays to examine the cytotoxic effects of doxorubicin on the human carcinomas”, Paridhi Anand, Carres Martinez, Kathleen Galm, and Natalia Coleman*, Mid-Atlantic Pharmacology Society Annual meeting, Philadelphia, December 10, 2010.
“Gradient and Patterned Polymer Brushes by Photoinitiated “Grafting Through” Approach”, T. Enright, D. Hagaman, M. Kokoruz, N. Coleman*, A. Sidorenko*, Journal of Polymer Science Part B: Polymer Physics. 2010, 48 (14), 1616-1622.
“In vitro maturation and early development capacity of bovine oocytes cultured in pure follicular fluid depending on its heat treatment and supplementation with follicular wall”, N. Coleman*, G. Shagiakhmetova, I. Lebedeva, T. Kuzmina, A. Golubev, Theriogenology, 67 .2007, 53-1059.
Contact Information
| Office location: | McNeil Science and Technology Center Room 344 |
| Mailing address: | Box 38 University of Sciences 600 South 43rd Street Philadelphia, PA 19104-4495 |
| Office Phone: | 215.596.7592 |
| Office Fax: | 215.596.8701 |
| Email: | n [dot] colema [at] usciences [dot] edu |