Kamal Jonnalagadda PhD

S. Kamal Jonnalagadda PhD

Associate Professor of Pharmaceutics

Education

BPharm (Birla-India)

PhD (Nebraska)

Research Interests

The research focus in our laboratory is the design, characterization, and the modeling of polymeric biomaterials for specific pharmaceutical applications. Applications include: (1) solid dosage forms: polymorphic transitions as a function of excipient concentration, storage (or ageing), and during the different stages of drug formulation, such as mixing, granulation, drying and compression. (2) biodegradable polymeric implants for macromolecular drug delivery and tissue engineering.

Synopsis

Dr. Jonnalagadda earned a Ph.D. from the University of Nebraska and a B.Pharm. from BIT, in India. He studies the design, characterization and modeling of polymeric biomaterials for specific pharmaceutical applications, including solid dosage forms and biodegradable polymeric implants for macromolecular drug delivery and tissue engineering.

Selected Scholarly Activity

C. Javiya, S. Jonnalagadda.  Physicochemical characterization of spray-dried PLGA/PEG microspheres, and preliminary assessment of biological response.  In Press, Drug Dev. & Industrial Pharmacy.  Jan 2016.

N. Panda, A. Biswas, K. Pramanik, S. Jonnalagadda.  Enhanced osteogenic potential of human mesenchymal stem cells on electrospun nanofibrous scaffolds prepared from eri-tasar silk fibroin.  Journal of Biomedical Materials, Part B., 103(5), 971-982, 2015.

N.N. Panda, S. Jonnalagadda, K. Pramanik.  Development and evaluation of cross-linked Collagen-Hydroxyapatite Scaffolds for Tissue Engineering. In Press, J. Biomat. Sci. Polym. Ed. (2013)

A. Rane, S. Jonnalagadda, Z. Li.  On-column refolding of bone morphogenetic protein-2 using cation exchange resin.  Protein expression and purification, 90, 135-140, 2013.

K.S.Gokhale, S. Jonnalagadda.  Preparation and evaluation of sustained release infliximab microspheres.  Accepted for publication in: PDA Journal of Pharmaceutical Science and Technology, 67(3), 255-266, 2013.

V. Waknis, S. Jonnalagadda.  Novel poly-DL-lactide-polycaprolactone copolymer based flexible drug delivery system for sustained release of ciprofloxacin.  Drug Delivery, 18(4), 236-245, 2011. 

J Gupta, C. Nunes, S. Vyas, S. Jonnalagadda.  Prediction of Solubility Parameters and Miscibility of Pharmaceutical Compounds by Molecular Dynamics Simulations.  J. Phy. Chem B, 115 (2014-2023), 2011.

P. Park, M.Makoid, S.Jonnalagadda.  The design of flexible ciprofloxacin-loaded PLGA implants using a reversed phase separation/coacervation method.  European J. Pharm. Biopharm., 77, 233-239, 2011.

K Shahani, S Jonnalagadda, H Handa, G Mao and J Panyam.  Phospholipid Nanoparticles: Process Optimization Using Fractional Factorial Design and Atomic Force Microscopy.  J. Biomed. Nanotech., 3(4), 394-400, 2007. 

V. Swaminathan, R. Tchao, S. Jonnalagadda.  Physical characterization of semi-porous  poly (lactide)/ poly (ethylene glycol) membranes for tissue engineering.  J. Biomat. Sci. Polym. Ed. 18(10), 1321-1333, 2007.

K. Garkhal, S. Verma, S. Jonnalagadda, N. Kumar.  Fast degradable Poly (L-lactide-co-e-caprolactone) microspheres for tissue engineering.  Synthesis, characterization, and degradation behavior.  J. Polym. Sci. Part. A. Polym. Chem.  45(13), 2755-2764, 2007.

R.G.Forcino, S. Jonnalagadda.  The effect of fabrication methods on the mechanical and thermal properties of PLGA scaffolds.  J. of Applied Polym. Sci., 104(2), 944-949, 2007.

P.Park, S. Jonnalagadda.  Predictors of glass transition in the biodegradable poly-lactide and poly-lactide-co-glycolide polymers.  J. of Applied Polym Sci., 100(3), 1983-87, 2006.

R. L. Graves, M.C. Makoid, S. Jonnalagadda.  The effect of coencapsulation of bovine insulin with cyclodextrins in ethylcellulose microcapsules.  J. Microencapsul.  22(6), 661-670, 2005.

S. Jonnalagadda, D.H.Robinson.  Effect of thickness and PEG addition on the hydrophilic degradation of PLLA.  J. Biomat. Sci. Polym. Ed., 15(10), 1317-26, 2004.

S. Jonnalagadda, D.H.Robinson.  Effect of the inclusion of PEG on the solid-state properties and drug release from polylactic acid films and microcapsules.  J. Applied Polym. Sci., 93(5), 2025-30, 2004. 

S. Jonnalagadda, D. H. Robinson.  A bioresorbable polylactide delivery system for diffusional and osmotic controlled drug delivery.  AAPS Pharm. Sci. Tech., 1:E29, 2000.

Contact Information

Office location: Robert McNeil Graduate Study and Research Center Room 106
Mailing address: Box 80
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
Office Phone: 215.596.8942
Email:

k [dot] jonnal [at] usciences [dot] edu