Grad Programs
Melissa G. Marko, PhD
Melissa G. Marko PhD
Visiting Assistant Professor, Department of Biological Sciences
Education
Teaching Post Doctoral Fellow, University of the Sciences
Post Doctoral Fellow, Georgetown University
Ph.D., Cell and Molecular Nutrition, Tufts University
M.S., Cell and Molecular Nutrition, Tufts University
B.S., Nutrition Science, Pennsylvania State University
B.S., Life Science, Pennsylvania State University
Research Interests
Bioengineering of Escherichia coli and Saccharomyces cervisiae
Role of antioxidants in cell signaling and mechanisms of health promotion
Synopsis
Current research is focusing on the biosynthetic pathway of the antioxidant carnosic acid found in the herb Rosmarinus officinalis or rosemary. Techniques in cellular and molecular biology are used to elucidate the biosynthetic pathway of carnosic acid from plant tissue, insertion of genes into genetically tractable microbial hosts, such as the bacteria Escherichia coli and the yeast Saccharomyces cervisiae, and the evaluation of the resulting bioengineered products.
Teaching Responsibilities
- Basic Nutrition
- Cell Biology Methods Lecture and Laboratory
- General Biology Laboratory
- Microbiology Laboratory
Selected Scholarly Activity
Marko M, Pang H-J E, Ren Z, Azzi A, Huber BT, Bunnell SC, Meydani SN. Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice. J Nutr. 139 (6): 1192-1197, 2009.
Marko M, Ahmed T, Bunnell SC, Wu D, Chung H, Huber BT, Meydani SN. Age-associated decline in effective immune synapse formation of CD4+ T cells is reversed by vitamin E supplementation. J Immunol. 178: 1443-1449, 2007.
Liu L, Zubik L, Collins FW, Marko M, Meydani M. The antiatherogenic potential of oat phenolic compounds. Atherosclerosis. 175 (1): 39-49, 2004.
Wu D, Marko M, Claycombe K, Paulson KE, Meydani SN. Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity. J Biol Chem. 278 (13): 10983-10992, 2003.
Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A. Defects in TGFβ Signaling Overcome Senescence of Mouse Keratinocytes Expressing v-rasHa. Oncogene 19: 1698-1709, 2000.
Wang D, Marko M, Dahl A, Engelke K, Placke M, Imondi A, Mulshine J, De Luca L. Topical Delivery of 13-cis Retinoic Acid by Inhalation Upregulates Expression of Rodent Lung, but not Liver Retinoic Acid Receptors. Clinical Cancer Research 6: 3636-3645, 2000.
Diamond I, Owolabi T, Marko M, Lam C, Glick A. Tetracycline Regulated Conditional Gene Expression in the Mouse Epidermis. The Journal of Investigative Dermatology 115 (5): 788-794, 2000.
Contact Information
| Office location: | McNeil Science and Technology Center Room 374 |
| Mailing address: | University of Sciences 600 South 43rd Street Philadelphia, PA 19104-4495 |
| Office Phone: | 215.596.7437 |
| Office Fax: | 215.596.8710 |
| Email: | m [dot] marko [at] usciences [dot] edu |