Charles N. McEwen PhD
Charles N. McEwen PhD
Houghton Endowed Chairholder in Chemistry and Biochemistry
Professor of Chemistry
BS (The College of William and Mary)
MS (Atlanta University)
PhD (University of Virgina)
Development of new and improved techniques in mass spectrometry, including atmospheric pressure ionization (API) and matrix-assisted laser desorption/ionization (MALDI), as applied to drug discovery, metabolomics and small molecule analysis.
Dr. McEwen holds a PhD from the University of Virginia. The immediate goal of his research program is to develop new ionization methods and integrate them into commercial atmospheric pressure (AP) ion sources making them capable of nearly universal ionization.
Selected Scholarly Activity
Trimpin, S.; Inutan, E. D.; Herath, T. N.; McEwen, C. N., Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Method for Selectively Producing Either Singly or Multiply Charged Molecular Ions. Anal. Chem. 2010, 82, 11-15.
Trimpin, S.; Inutan, E.D.;Herath, T.N. and McEwen, C.N. Laserspray ionization - A New AP-MALDI Method for Producing Highly Charged Gas-Phase Ions of Peptides and Proteins Directly from Solid Solutions, Mol. and Cell. Proteomics, 2009, M900527-MCP200.
McEwen, C. N.; Larsen, B. S “Ionization Mechanisms Related to Negative Ion APPI, APCI, and DART” J. Of The American Soc. For Mass Spectrometry 2009, 20, 1518-1521.
Lloyd, J. A.; Harron, A. F; McEwen, C. N. "Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source", Anal. Chem., 2009, 81, 9158-9162.
Trimpin, S.; Wijerathne, K.; McEwen, C. N. “Rapid methods of polymer and polymer additives identification: Multi-sample solvent-free MALDI, pyrolysis at atmospheric pressure, and atmospheric solids analysis probe mass spectrometry” Analytica Chimica Acta 2009, 654, 20-25.
Ionkin, A. S.; Marshall, W. J.; Fish, B. M.; Schiffhauer, M. F.; Davidson, F. and McEwen, C. N. “Highly Unsaturated Phosphorus Compounds: Generation and Reactions on Both Multiple Bonds of Vinyl Phosphaalkyne" Organometallics, 2009, 28 , 2410-
McEwen, CN, GC/MS on an LC/MS instrument using atmospheric pressure photoionization, Int J Mass Spectrom, 259, 57-64, 2007.
Trimpin S, Clemmer DE, McEwen CN, Charge-remote fragmentation of lithiated fatty acids on a TOF-TOF instrument using matrix-ionization, J Am Soc Mass Spectrom, 18, 1967-1972, 2007.
Trimpin S, Weidner SM, Falkenhagen J, McEwen, CN, Fractionation and solvent-free MALDI-MS analysis of polymers using liquid adsorption chromatography at critical conditions in combination with a multisample on-target homogenization/transfer sample preparation method, Anal Chem, 79, 7565-7570, 2007.
Trimpin S, McEwen CN, Multisample preparation methods for the solvent-free MALDI-MS analysis of synthetic polymers, J Am Soc Mass Spectrom, 18, 377-381, 2007.
McEwen CN, McKay RG, Larsen BS, Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments ,Anal Chem, 77, 7826-7831, 2005.
McEwen CN, McKay RG , A combination atmospheric pressure LC/MS : GC/MS ion source: Advantages of dual AP-LC/MS : GC/MS instrumentation, J Am Soc Mass Spectrom, 16, 1730-1738, 2005.
Clements A, Johnston MV, Larsen BS, McEwen CN, Fluorescence-based peptide labeling and fractionation strategies for analysis of cysteine-containing peptides , Anal Chem, 77, 4495-4502, 2005.
Fagan PJ, Krusic PJ, McEwen CN, Production of perfluoroalkylated nanospheres from buckminsterfullerenes, Science, 262, 404-407, 1993.
McEwen CN, McKay RG, Larsen BS, C-60 as a radical sponge, J Am Chem Soc, 114, 4412-4414, 1992.
McEwen CN, Rudat MA, Radical trapping in a mass spectrometer ion source,1 , J Am Chem Soc, 103, 4343-4349, 1981.
|Office location:||Griffith Hall Room 325|
|Mailing address:||Box 48|
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
c [dot] mcewen [at] usciences [dot] edu