Grad Programs
Diane W. Morel PhD
Diane W. Morel PhD
Assistant Dean of Curricula and Assessment, Philadelphia College of Pharmacy
Associate Professor of Pharmacology and Toxicology
Education
BA (Douglass)
MS (Case WesternReserve)
PhD (Case WesternReserve)
Research Interests
Oxidized lipids and lipoproteins in disease Role of vitamin E and specific carotenoids in limiting endothelial cell-mediated lipoprotein oxidation Intracellular transport and interactions between cholesterol and oxidized sterols Effect of antioxidants on lipoprotein oxidation and antherogenesis in cholesterol-fed rabbits Subsets of patients at risk for cardiovascular disease
Synopsis
Dr. Morel's research seeks to understand the mechanisms by which oxidative and nitrative species contribute to changes in cellular function in chronic disease, and how dietary components or antioxidants may protect against these changes.
Selected Scholarly Activity
Beauchamp, GK, RSJ Keast, DW Morel, J Lin, J Pika, Q Han, C Lee, AB Smith and PAS Breslin. (2005) Ibuprofen-like activity in extra-virgin live oil. Nature 437:45-46.
McDevitt, TM, R Tchao, EH Harrison and DW Morel (2005) Carotenoids normally present in serum inhibit proliferation and induce differentiation of a human monocyte/macrophage cell line (U937). J. Nutrition 135:160-4.
During, A, MH Hussain, DW Morel and EH Harrison (2002) Carotenoid uptake and secretion by CaCo-2 cells: B-carotene isomer selectivity and carotenoid interactions. J. Lipid Res. 43:1086-95.
Dugas, TR, EH Harrison and DW Morel (2000) Novel cell culture medium for use in oxidation experiments provides insights into mechanisms of endothelial cell-mediated oxidation of low density lipoprotein. In Vitro Cellular and Developmental Biology 36:571-577.
Dugas, TR, DW Morel and EH Harrison (1999) Dietary Supplementation with b-carotene, but not with lycopene, inhibits endothelial cell-mediated oxidation of low density lipoprotens. Free Rad. Biol. Med. 26:1238-44.
Contact Information
| Office location: | Pharmacology/Toxicology Center Room 239 |
| Mailing address: | Box 118 University of Sciences 600 South 43rd Street Philadelphia, PA 19104-4495 |
| Office Phone: | 215.895.1123 |
| Email: | d [dot] morel [at] usciences [dot] edu |