Kenneth Myers PhD

Kenneth Myers PhD

Assistant Professor of Biology

Education

BS, Biology, Philadelphia University – 2002
PhD, Molecular, Cellular Biology & Genetics, Drexel University College of Medicine – 2007
Postdoctoral Fellow and Intramural Research Training Associate, NHLBI, NIH – 2012

Research Interests

My research interests focus on the mechanisms by which endothelial cells alter their microtubule dynamics to elaborate cell branches and thereby establish directed motility, as well as the response of microtubule dynamics to physical interactions with the extracellular matrix. My work combines high-resolution light microscopy and automated tracking of microtubule dynamics in human umbilical vein endothelial cells. To aid in understanding how the physical environment influences cell morphology I culture cells onto 3-dimensional collagen matrices, or onto micro-fabricated substrates of various shapes, and utilize these approaches to test hypotheses relevant to vascular development and diseases associated with endothelial cell angiogenesis.

Synopsis

Dr. Myers research is focused on proteins that regulate the dynamic behaviors of the microtubule cytoskeleton and thereby modulate endothelial cell branching and directional motility during vascular development, maintenance and angiogenesis. For more information, see www.myerslabusci.com.

Selected Scholarly Activity

Braun A., Dang K., Buslig F., Baird M.A., Davidson M.W., Waterman C.M., Myers K.A.  Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells.  Journal of Cell Biology.  206:97-112. 2014.

Joshi M.R, Yao N., Myers K.A., Li Z.  Human serum albumin and p53-activating peptide fusion protein is able to promote apoptosis and deliver fatty acid-modified molecules.  PLoS One.  8(11):e80926.  2013.

Caesar NM, Myers KA, Fan X.  Neisseria meningitidis serogroup B vaccine development.  Microbial Pathogenesis.  57:33-40, 2013

Fischer RS, Myers KA, Gardel ML, Waterman CM. Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior. Nat Protoc. 2012. Nov;7(11):2056-66. PMID:23099487.

Myers K.A., Applegate K., Danuser G., Fischer R.S., and Waterman C.M. Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis. Journal of Cell Biology. 192(2):321-34, 2011.

Shin,W.D., Fischer R.S., Kanchawong P., Kim Y., Lim J., Myers, K.A., Nishimura Y., Plotnikov S.V., Thievessen I., Yarar D., Sabass B., Waterman C.M. A versatile, multicolor total internal reflection fluorescence and spinning-disk confocal microscope system for high-resolution live cell imaging. In Live cell imaging: A laboratory manual, 2nd ed. (ed. Goldman RD, Swedlow JR, Spector DL), pp. 119-138. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 2010.

Nadar V.C., Ketschek A., Myers, K.A., Gallo G., Baas P.W. Kinesin-5 is essential for growth cone turning. Current Biology. 18(24):1972-7, 2008.

Myers, K.A. and Baas P.W. Microtubule-Actin Interactions During Neuronal Development. In: The Neurobiology of Actin: From Neurulation to Synaptic Function. Springer Publishing Co.: New York, NY, 2008.

Baas, P.W., Myers, K.A., Qiang L., and Nadar V.C. Microtubules: organization and function in neurons. In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, American Press, Oxford. 2008.

Myers, K.A. and Baas P.W. Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array. The Journal of Cell Biology. 178(6): 1081-1091, 2007.

Myers, K.A., Tint I., Nadar C.V., He Y., Black M.M., Baas P.W. Antagonistic forces generated by cytoplasmic dynein and myosin II during growth cone turning and axonal retraction. Traffic. 7(10):1333-51, 2006.

Ahmad F.J., He Y., Myers, K.A., Hasaka TP, Francis F, Black MM, Baas PW. Effects of dynactin disruption and dynein depletion on axonal microtubules. Traffic. 7(5):524-37, 2006.

Baas P.W., Nadar V.C., Myers, K.A. Axonal transport of microtubules: the long and short of it. Traffic. 7(5):490-8, 2006.

Myers, K.A., He Y., Hasaka T.P., Baas P.W. Microtubule transport in the axon: re-thinking a potential role for the actin cytoskeleton. Neuroscientist. 12(2):107-18, 2006.

He Y., Francis F., Myers, K.A., Yu W., Black M.M., Baas P.W. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. Journal of Cell Biology. 168(5):697-703, 2005.

Myers, K.A., Hasaka T.P., Baas P.W. Role of actin filaments in the axonal transport of microtubules. Journal of Neuroscience. 24(50):11291-301, 2004.

Baird D.H., Myers, K.A., Mogensen M., Moss D., Baas P.W. Distribution of the microtubule- related protein ninein in developing neurons. Neuropharmacology. 47(5):677-83, 2004.

Contact Information

Office location: McNeil Science & Technology Center, Room 348
Mailing address: University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
Office Phone: 215-596-7531
Office Fax: 215-596-8710
Email:

k [dot] myers [at] usciences [dot] edu