Steven Neau PhD
Steven Neau PhD
Director of Industrial Pharmacy
Director, Graduate Pharmaceutics Program
Professor of Pharmaceutical Sciences
BS (Eastern Michigan University)
BA (Eastern Michigan University)
MS (University of Michigan)
PhD (University of Michigan)
Formulation development Polymer use in formulations
Physical chemistry applications in pharmacy
Use of enzymes in prodrug synthesis
Dr. Neau earned a PhD and MS from the University of Michigan, and a BS and BA from Eastern Michigan University. He studies pharmaceutical applications of polymeric materials in the analysis and delivery of drugs, with an emphasis on the use of polymers to achieve sustained or colon-specific drug release following oral administration of the product. His research efforts have resulted in nearly 50 journal articles and book chapters, and more than 60 presentations at national and international scientific conferences.
The research conducted by my group is in the Physical Pharmacy and Formulation Development areas. We have explored pharmaceutical applications of polymeric materials in the analysis and delivery of drugs. In particular, we are focusing on the use of polymers to achieve sustained or colon-specific drug release following oral administration of the product. Colon-specific drug delivery is important in the treatment of localized diseases and conditions, such as Crohn's disease, ulcerative colitis, colorectal cancer and amoebiasis. Peptides, proteins and vaccines pose potential candidature for colon targeted drug delivery for systemic absorption since they are susceptible to degradation by enzymes found in the small intestine. The polymer establishes a release controlling matrix throughout the dosage form or only within a coating applied to the bead or tablet. Research efforts have resulted in 46 journal articles and book chapters, as well as 63 presentations at national and international scientific conferences. Students involved in these research projects have earned B.S., Pharm.D., M.S. and Ph.D. degrees and now hold positions in academia and in the medical and pharmaceutical industry.
Selected Scholarly Activity
"Extruded and Spheronized Beads Containing Carbopol® 974P to Deliver Nonelectrolytes and Salts of Weakly Basic Drugs,"G. S. Bommareddy, S. Paker-Leggs, K. K. Saripella, and S. H. Neau, Int. J. Pharm., In Press.
"Polyethylene Oxide and Methoxypolyethylene Glycol in the Production of High Drug Load Extruded and Spheronized Beads That Are Devoid of Microcrystalline Cellulose,"M. A. Howard, S. H. Neau, and M. J. Sack, Int. J. Pharm., 307, 66-76 (2006).
"Modulating Intestinal Uptake of Atenolol using Niosomes as Drug Permeation Enhancers,"I. A. Alsarra, A. A. Bosela, A. M. Al-Mohizea, G. M. Mahrous, and S. H. Neau, Scientia Pharmaceutica, 73, 81-93 (2005).
"Water Distribution Studies within Microcrystalline Cellulose and Chitosan using Differential Scanning Calorimetry and Dynamic Vapor Sorption Analysis,"A. M. Agrawal, R. V. Manek, W. M. Kolling, and S. H. Neau, J. Pharm. Sci., 93, 1766-1779 (2004).
"Extruded and Spheronized Beads Containing No Microcrystalline Cellulose: Influence of Formulation and Process Variables,"A. M. Agrawal, M. A. Howard, and S. H. Neau, Pharm. Dev. Technol., 9, 197-217 (2004).
"Effects of Preparative Parameters on the Properties of Chitosan Hydrogel Beads Containing Candida Rugosa Lipase,"I. A. Alsarra, S. H. Neau, and M. A. Howard, Biomaterials, 25(13), 2645-2655 (2004).
"Studies of the Interaction between Water and Ethylcellulose: Effect of Polymer Particle Size,"A. M. Agrawal, R. V. Manek, W. M. Kolling, and S. H. Neau, AAPSPharmSciTech, 4(4) Article 60 (2003) http://www.aapspharmscitech.org/view.asp?art=pt040460.
"Wet Granulation Fine Particle Ethylcellulose Tablets: Effect of Production Variables and Mathematical Modeling of Drug Release,"A. M. Agrawal, S. H. Neau, and P. L. Bonate, AAPSPharmSci, 5(2) Article 13 (2003) http://www.aapspharmsci.org/volsIssues/issueView.asp?vol=05&issue=02.
"Molecular Weight and Degree of Deacetylation Effects on Lipase-Loaded Chitosan Bead Characteristics,"I. A. Alsarra, S. S. Betigeri, H. Zhang, and S. H. Neau, Biomaterials, 23, 3637-3644 (2002).
"Immobilization of Lipase using Hydrophilic Polymers in the Form of Beads,"S. S. Betigeri and S. H. Neau, Biomaterials, 23, 3627-3636 (2002).
"In Vitro Degradation of Chitosan by Bacterial Enzymes from Rat Cecal and Colonic Contents,"H. Zhang and S. H. Neau, Biomaterials, 23, 2761-2766 (2002).
"A Chitosan-Containing Multiparticulate System for Macromolecule Delivery to the Colon,"H. Zhang, I. A. Alsarra, and S. H. Neau, Int. J. Pharm., 239, 197-205 (2002).
"Fine Particle Ethylcellulose as a Tablet Binder in Direct Compression, Immediate Release Tablets,"R. P. Desai, S. H. Neau, S. I. Pather, and T. P. Johnston, Drug Dev. Ind. Pharm., 27, 35-43 (2001).
"In Vitro Degradation of Chitosan by a Commercial Enzyme Preparation: Effect of Molecular Weight and Degree of Deacetylation,"H. Zhang and S. H. Neau, Biomaterials, 22, 1653-1658 (2001).
"Lipase-Catalyzed Enantioselective Esterification of Flurbiprofen with n-Butanol," S. V. Bhandarkar and S. H. Neau, EJB: Electr. J. Biotechnol., 3(3), (Dec 15, 2000). http://www.ejbiotechnology.info/content/vol3/issue3/index.html#research.
"Evaluation of Quantitative Structure Property Relationships Necessary for Enantioresolution with Lambda-Carrageenan and Sulfobutylether Lambda-Carrageenan,"G. M. Beck, S. H. Neau, A. J. Holder, and J. N. Hemenway, Chirality, 12, 688-696 (2000).
"The Optimization of Lambda-Carrageenan as a Chiral Selector in Capillary Electrophoresis Separations,"G. M. Beck and S. H. Neau, Chirality, 12, 614-620 (2000).
"Formulation and Process Considerations for Beads Containing Carbopol® 974P, NF Resin,"S. H. Neau, M. Y. Chow, G. A. Hileman, M. J. Durrani, F. Gheyas, and B. A. Evans, Int. J. Pharm., 199, 129-140 (2000).
|Office location:||Alumni Hall Room 2|
|Mailing address:||Box 80|
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
s [dot] neau [at] usciences [dot] edu