Bela Peethambaran PhD
Bela Peethambaran PhD
Associate Professor of Biology
BS (St. Xavier’s College, Gujarat University, India)
PhD (Mississippi State University)
My laboratory is using molecular biology, genetic, biomechanical and physiological tools to engineer plants as a resource for antioxidants and bioactive compounds such as phenolics and flavanols.
- studying effects of plant polyphenols on cancer cells
- investigating if plant secondary metabolites could be used as natural pesticides
- study plants that have anti-acne and ant-aging characteristics.
Our research integrates several disciplines such as molecular biology, cell biology, biotechnology and pharmacognosy to investigate the different genes that regulate biosynthesis of natural products in plants. We are also isolating, identifying novel natural products and investigating its application as anti-microbial. Several compounds isolated from novel herbs are also being studied for its potential use as alternative/complementary medicine in cancer prophylaxis.
Selected Scholarly Activity
Shah R., Patel T., Tettamanzi M.C., Rajan J., Shah M., Peethambaran B (2016). Isolation of a Novel Piperidide from Achillea ‘Moonshine’ Using Bioactivity Guided Fractionation for the Treatment of Acne. Journal of Medicinal Plant Research. 10 (30):. 495-504
Abeer Badiab, Fizal Nabbie, Maria Cristina Tettamanzi, Nehi Patel, Nikita Jain, B Peethambaran (2016). Specific Cytotoxicity of a Novel Arbutin Derivative from Myrothamnus flabellifolius Against Human Leukemia Cells. Research Journal in Medicinal Plants. DOI: 10.3923/rjmp.2016.http://scialert.net/onlinefirst.php?issn=1819-3455
B. Peethambaran, V. Miller, Justine, K. Kermalli. Jiaxing. J, G. Fridman, R. Balsamo and A. Fridman. (2016). Non-thermal Plasma Technology (NTPT) Reduces Water consumption while Accelerating Arabidopsis thaliana Growth and Fecundity. Plasma Medicine, 5(2-4)87-98.
Balsamo R, Boak M, Nagle K, Peethambaran B, Layton B. Leaf biomechanical properties in Arabidopsis thaliana polysaccharide mutants affect drought survival. J Biomech. (2015) Nov 26;48(15):4124-9. doi: 10.1016/j.jbiomech.2015.10.016. Epub 2015 Oct 20. PubMed PMID: 26520913.
Shah, R., Patel, A., Shah, M., Peethambaran B. (2015). Anti-acne activity of Achillea ‘Moonshine’ petroleum ether extract. Journal of Medicinal Plants Research. Journal of Medicinal Plant Research 9(27):755-63
Dhillon, J., Miller, V., Badiab A., Tang CN., Huynh A., Peethambaran, B. 2014. Apoptosis-inducing potential of Myrothamnus flabellifolius, an edible medicinal plant, on human myeloid leukemia HL-60 cells. International Journal of Applied Research in Natural Products, 7:28-32
Tran, L., Naik, A., Koronkiewicz, B., Peethambaran, B. 2014. Epigallocatechin gallate Inhibits Biofilm Production and Attenuates Virulent Factors of Pseudomonas aeruginosa and Psuedomonas fluorescence. Journal of Natural Remedies, 14:106-111
Lindberg, J., Nabbie, F., Milliot, J., Smith, R., M Crisitina Tettamanzi., Peethambaran, B. 2014. 14-3-3λ Affects Production of a Sinapoyl Derivative in Lignin Biosynthesis during Drought Stress in Arabidopsis thaliana. Universal Journal of Plant Sciences, Vol 2, no. 4: 77-85
Smith, R., Peethambaran B., Pontiggio, L., Blumberg, P. 2013. Does a repeated guided-instruction approach with multiple assessments increase student learning of science? Journal of Biological Education , 47: 11-116
Peethambaran, B., Li, T C., Dzugan, P., Xiang, W., Balsamo, R. A. 2012. Physiological and Mechanical Role of 14-3-3 lambda in Arabidopsis thaliana during drought stress. 2012 Journal of Agricultural Science, 4: 149-163
Kelly, R. Y., Harper, J., Bridges, S. M. Warbuton, M. L., Hawkins, L. K., Pechanova, O., Peethambaran, B., Luthe, D. S., Mylroie, J. E., Ankala, A., Ozkan, S., Gresham, C., Henry, W. B., Williams, W. P. 2010. Bioinformatics and Functional Genomic Database for Identifying Candidate Genes for Aspergillus flavus Resistance in Maize. BMC Bioinformatics 11 (Suppl 6):S25
Peethambaran, B., Hawkins, L., Bridges, S., Windham, G. L., Williams, W. P and Luthe, D. S. 2009. Antifungal Activity of Maize Silk Proteins and Role of Chitinases in Aspergillus flavus resistance. Journal of Toxicology - Toxin reviews. 29: 27-39
Poster presentation by graduate student on ‘Effects of 14-3-3λ on the biosynthesis of flavonoids in Arabidopsis thaliana’ Presenter: Jameson Lindberg, Robert Smith, Bela Peethambaran., International Congress on Natural Products Research 2013, St. Lois, Kansas, July 15th- Jul 18th.
Poster presentation by graduate student on ‘Screening and characterization of anti-acne and anti-aging properties in Achillea millefolium and Veronicastrum virginicum’ Presenter: Rahul Shah, Abhishek Patel, Bela Peethambaran., International Congress on Natural Products Research 2013, St. Lois, Kansas, July 15th- Jul 18th.
Poster presentation on ‘Effects of 14-3-3λ on the biosynthesis of flavonoids in Arabidopsis thaliana’ Presenter: Jameson Lindberg, Robert Smith, Bela Peethambaran., International Congress on Natural Products Research 2012, New York city, Grand Hyaat, Jul 28th-Aug 12th, 2012.
Poster presentation on ‘Which hydroxyl groups of epigallactocatechin gallate are needed for binding to DNA G-quadruplexes? Presenter: Brian, Koronkiewicz, Nathan West, Bela Peethambaran, Michael Bruist. June 2nd, 2012, Mid-Atlantic Regional Meeting for ACS, Baltimore, abstract 466 http://marmacs.org/2012/docs/MARM-2012-Program-Book.pdf
Poster presentation on ‘The role of 14-3-3 lambda protein in secondary metabolite biosynthesis and its effect on drought stress resistance’. Annual Plant Biology meeting 2011, Aug 6-10, Minneapolis, MN http://abstracts.aspb.org/pb2011/public/P13/P13027.html
Oral presentation on’ Cellulose Microfibril Arrangement Influences Drought Tolerance in Eragrostis’. Speaker: Balsamo, R. A; Peethambaran, B; Boyd, M. B and Layton, B. E. USDA-AFRI Grant Awardee Meeting Washington DC November 2009.
Oral presentation on ‘Intra-species approach to developing a nanomechanical model of drought and desiccation tolerance in plants’. Speaker :Layton, B. E; Boyd, M. B.; Peethambaran, B., Balsamo, R. A., USDA/CSREES-AFMNet Joint Nantoechnology Grantees Meeting. September 27-28, 2009. Hilton Santa Fe Historic Plaza, Santa Fe, NM
Poster presentation on ‘The 14-3-3 nu protein regulates the flg22- induced oxidative burst’. 19th International conference on Arabidopsis research. Hyatt Regency Hotel. July 23-27, 2008 Montreal, Canada Oral and poster presentation on ‘A 14-3-3 protein functions in plant defense against pathogens’, Gordon Conference on 14-3-3 proteins, Crowne Plaza. Feb 24-29, 2008 Ventura, CA http://www.grc.org/programs.aspx?year=2008&program=14-3-3
- Teaching Post Doctoral Fellow, Biology Department, Villanova University, Villanova, PA
- Research Post Doctoral Fellow, Biology Department, University of Minnesota, St. Paul, MN.
|Office location:||McNeil Science & Technology Center, Room 271|
|Mailing address:||Box 38|
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
b [dot] peethambaran [at] usciences [dot] edu