Marvin Schulte PhD

Marvin Schulte PhD

Marvin Schulte PhD

Chair, Department of Pharmaceutical Sciences

The McNeil Research Professor

Professor of Pharmaceutical Sciences

Education

Ph.D. (Department of Biochemistry, University of Minnesota)

Synopsis

Dr. Schulte earned a B.S. degree from St. John’s University, Collegeville, MN and a Ph.D. from the University of MN.  He was a post-doctoral fellow in Dr. Michael White’s laboratory at the Medical College of Pennsylvania (now merged with Drexel University).  He has held previous faculty appointments at the University of Louisiana Monroe, College of Pharmacy and the University of Alaska Fairbanks. He is currently the McNeil Professor of Pharmacology and Toxicology and Chair of the Department of Pharmaceutical Sciences. He has been involved in multiple program building initiatives and strategic planning efforts, spanning both academic and research development. His laboratory provides ample training opportunities for students including those at the high school, undergraduate and graduate levels. Early in his career, Dr. Schulte was the recipient of an NSF CAREER award to develop team approaches to student laboratory research and he continues to use this approach in his laboratory today.

Dr. Schulte's research has focused on the structure and function of ligand gated ion channels for over 20 years. Ligand gated ion channels include serotonin type 3 receptors, nicotinic receptors and GABA receptors. Dr. Schulte works to identify, characterize and advance novel drug leads targeting these important central nervous system receptors as potential therapeutic agents and research tools. Specific questions being addressed in Dr. Schulte's laboratory include allosteric modulators of nicotinic receptor function, novel antidepressants, drugs for use in smoking cessation and the role of ligand gated ion channels in neurological diseases such as Autism and Schizophrenia. Recognizing that comprehensive understanding comes through substantive collaborative research, Dr. Schulte works extensively with other researchers in the areas of Medicinal Chemistry, Biophysics, Pharmacology, Physiology and Chemical Engineering, Common approaches in his laboratory include voltage clamp, patch clamp and extracellular electrophysiology, surface plasmon resonance and techniques for protein production, modification and purification. 

Selected Scholarly Activity

Dukat, M., Alix K., Worsham J., Khatri S. and Schulte M.K. (2013), "2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character." Bioorg. Med. Chem. Lett., In Press.

Weltzin, M.M. and Schulte M.K. (2012) "Allosteric modulation of high and low affinity α4β2 nicotinic acetylcholine receptors by HEPES."  E. J. Pharm.  Epub ahead of print.

Buchapudi K., Han M., Xu X., Ataian Y., Ji H.-F., Schulte M.K. (2012)  "Micromechanical Measurement of AChBP Binding for Label-free Drug Discovery." Analyst, 137(263-271).

German N, Kim JS, Jain A, Dukat M, Pandya A, Ma Y, Weltzin M, Schulte MK, Glennon RA (2011) "Deconstruction of the α4β2 nACh receptor positive allosteric modulator des-formylflustrabromine (dFBr)."  J. Med. Chem.  54(20):7259-67.

Weltzin, M.M. and Schulte MK (2010) "Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with α4β2 nAChR Orthosteric ligands." JPET, 334(3):917-26.

Hazai E, Joshi P, Skoviak EC, Suryanarayanana A, Schulte MK and Bikadi Z. (2009)  "A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanide."  Bioorg Med Chem, 17(16), 5796-5805.

Ji, H.F., Gao, H., Buchapudi, K.R., Yang, X., Xu X. and Schulte M.K. (2008)  "Microcantilever biosensors based on conformational change of proteins." Analyst, 133(4), 434-443.

Hongyan G., Buchapudi, K.R. Smyth, A., Schulte, M.K. and Ji, H-F. (2008) "An Improved Surface Modification Approach for Micromechanical Biosensors." Lanmuir, 24(2), 345-349.

Kim J.S., Pandya A., Weltzin, M.M., Edmonds, B.W., Schulte, M.K. and Glennon R.A. (2007) "Synthesis of desformylflustrabromine and its re-evaluation as an alpha4/beta2 nACh receptor modulator." Bioorganic and Med Chem Letters. 17(17):4855-60.

Contact Information

Office location: Pharmacology and Toxicology Center, Room 242
Mailing address: Department of Pharmaceutical Sciences
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
Office Phone: 215.596.8903
Email:

m [dot] schulte [at] usciences [dot] edu